Top 10 reasons for decreased dopamine synthesis
- NOT a lack of dopamine pf drugs! Why not ask why you may have a lack of dopamine synthesis instead of taking synthetic dopamine drugs & all their side effects!
- Dysglyemia alters large neutral amino acid transportation which allows tyrosine to cross the blood brain barrier (BBB). Tyrosine then can be converted to DOPA by tyrosine hydroxylase enzyme. This enzyme is dependent on proper oxygen and no anemia, iron levels and folinic (not folic acid) levels. Lastly, DOPA converts into DOPAMINE by the AAAD enzyme and is Pyridoxal-5-Phosphate dependent. Alcohol depletes this!
- Anemia – Low oxygen is the result of Anemia (low RBC’s or poor-quality RBC’s).
- Alcohol – depletes Pyridoxal -5-Phosphates (P5P). Without P5P, you cannot convert DOPA into Dopamine!
- Chronic depression medication use. SSRI drugs also promote P5P deficiency.
- Dysbiosis – Promotes a decrease in tetrahydrobiobiopterim (THB). THB is derived from Folinic (NOT FOLIC ACID).
- Iron Deficiency alters tyrosine hydroxylase function.
- Liver Dysfunction – Problems with phase I & phase 2 liver detoxification, poor methylation, and acute wind up of liver immune inflammatory Kupper Cells will not allow for phenylanine to properly convert to tyrosine. Medications, drugs, and alcohol also negatively impact liver function.
- COMT enzyme. Catechol-o-methyl transferase (COMT) is how dopamine is broken down for normal dopamine use and proper signaling. If COMT activity is decreased, then this will cause loss of dopamine synaptic clearance and in time alters dopamine receptors’ signaling and overall brain function. Poor methylation is a major cause of decreased COMT activity. Hypothyroidism, antacids, H. pylori infection, birth control or hormone replacement drugs all cause poor methylation and in return decrease COMT and can cause dopamine dysfunction.
- Foods that increase phenylalanine and tyrosine which helps promote DOPAMINE synthesis are the following: wild game meat, beef, pork, fish, turkey, eggs, cheese, oats, and chocolate.
If you have never been told about the top 10 promoters of dopamine production by your doctor, then find another doctor trained in how these biochemical dysfunctions can help you heal and restore normal function. For more info please call Dr. Farley at (973) 539-3311, or visit www.drjamesfarley.com.